From the perspective of the Holy Quran, although God has created humans to choose and elect a free God, they do not have the choice to have it (God) or not. Because in the monotheistic worldview, if a person does not worship God, he will fall into the worship of the self (self-worship) or the worship of another (idols, pharaohs, devils, etc.). In this view, if humans follow the path of worshiping God, they will be under the guardianship of God, and if they follow the path of worshiping someone other than God, they will be under the guardianship of the devil. Accordingly, social systems are not exempt from two states; they are either formed on the path of worshiping God or on the path of worshiping someone other than God. Therefore, it can be said that the type of worship is the origin of the formation of the two systems of truth and falsehood, the main aspect of distinction and the starting point of conflict between the two. Therefore, the front of the prophets and guardians (peace be upon them) on the path of exalting the word of monotheism will have a constant struggle with tyrants until the complete destruction of falsehood. In this article, which is descriptive-analytical, an attempt has been made to examine the concept of guardianship and its place in the form and orientation of social systems from the perspective of Ayatollah Sayyid Muhammad Mahdi Mir Baqeri, and using the views of this Shiite thinker.